Web1 mrt. 1990 · An increase in body weight of over 5%, or a rise in systolic or diastolic blood pressure of over 10 mmHg on two separate visits, were scored as treatmentrelated events. The biochemical parameters were evaluated according to standard WHO criteria. Websupine blood pressure, made worse by standing, was also observed initially. These volunteers developed tolerance to the cardiovascular and subjective adverse CNS effects of dronabinol within 12 days of treatment initiation. Tachyphylaxis and tolerance do not, however, appear to develop to the appetite stimulant effect of MARINOL Capsules.
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